[ACS] Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli

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journal£ºJournal of Medicinal Chemistry

Authors£ºFabian Hulpia; Wim Schepens; Susan Lepri; Johan Nicola; Zhengyu Jiang; Sylvia F. Boj; Tammy L. Bush; Mary-ambre Carvalho; Falian Chen; Gerald Chu; Kathleen W. Clancy; Zienab Etwebi; Melissa Everaerts; Yi Fan; Froylan Omar Fernandez Candelaria; Albi Francis; Mark S. Hixon; Ferran Jardi; Shuai Jin; Egor M. Larin; Stefaan Last; Joseph E. Leenaerts; Siyu Li; Alexandra G. Liddane; Ferdinand H. Lutter; Dan Lv; Bethany Mattson; Cynthia M. Milligan; Aaron N. Patrick; Gauri Anand Patwardhan; Laura Perez-Benito; Serge Pieters; Evelien Renders; Ed Retzbach; Constance Smith-Monroy; Jos¨¦ Silva; Mariana Silva; Hans Sterckx; Gerben ten Hag; Claudia Thte; Sven Van Brandt; Carla S. Verissimo; Guido Verniest; Eileen Vesely; Irene Vetrano; Petra Vinken; Yufei Wang; Victoria Wong; Xuemei Yao; Jie Yang; Remco Zijlmans; Kurtis E. Bachman; David Pocalyko; Juan-Miguel Jimenez; Dana Gaffney; Jan Willem Thuring

Published date£º2025-11-27

DOI£º10.1021/acs.jmedchem.5c00830

PDF link£ºhttps://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c00830

Article link£ºhttps://doi.org/10.1021/acs.jmedchem.5c00830

Article Source£ºAmerican Chemical Society (ACS)¡£


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rdoca Post time 2026-2-13 17:53:48 | Show all posts

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