[Other] Comparison of the efficacy and clinical applications of three different myopia control methods: repeated low-level red light, 1% atropine, and orthokeratology lenses in children and adolescent Copy

Currently, the mainstream methods for myopia control include atropine, orthokeratology lenses(OK lens), and repeated low-level red light (RLRL). In-depth exploration of different intervention methods are of great significance.

600 participants aged 8–16 years with a spherical equivalent (SE) of − 0.50 to − 7.50 D (D) completed 8 months treatment. They were divided into four groups: the RLRL, 1% atropine, OK lens and control (single-vision spectacles [SVS]) group. Each group comprised 150 patients .

At baseline, the difference was not statistically significant in the AL of the RLRL, 1% atropine, OK, and SVS groups (P&#8201;>&#8201;0.05); After 8 months, significant differences were observed between the OK group and the RLRL, 1% atropine, SVS groups (P&#8201;<&#8201;0.05). However, no statistically significant difference was found between the RLRL and 1% atropine groups. In the RLRL group, the difference in axial length (AL) progression between low myopia(LM) and high myopia(HM) subgroups was statistically significant (P&#8201;<&#8201;0.05). the corneal curvature KI and K2 were statistically nonsignificant before and after the intervention(P&#8201;>&#8201;0.05).At baseline, the SEs were not significantly different (P&#8201;>&#8201;0.05). After 8 months. the OK, RLRL, and 1% atropine groups showed statistically significant differences in SE compared to the SVS group (P&#8201;<&#8201;0 0.05).

RLRL, 1% atropine, and OK lenses were effective in controlling AL and SE increase compared with SVS, with RLRL and 1% atropine exhibiting better outcomes than OK lenses.