[Other] Design of Novel Exatecan-Amide Linker-Payloads for the Development of Stable, Low-Aggregating, and Highly Efficacious Antibody-Drug Conjugates

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journalㄩJournal of Medicinal Chemistry

AuthorsㄩRyan V. Quiroz; Simon B. Lang; Rebecca E. Johnson; Nancy Zepeda; Vlad Bacauanu; Christian L. Morales; Manoj Charati; John A. Flygare; Olivia R. Chastain; Zhong L. Hua; Edward P. Bowman; Bernhard H. Geierstanger; Alycia K. Uyeoka; Fan Zhang; Huimin Zhong; Esther Kofman; Daniela M. Tomazela; Laurence Fayadat-Dilman; Mengxuan Jia; Michael Judo; Ian Knemeyer; Peyman Akbari; Qingyun Yan; Evan R. Barry; Alan B. Northrup; W. Michael Seganish

Published dateㄩ2026-5-14

DOIㄩ10.1021/acs.jmedchem.5c03706

PDF linkㄩhttps://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c03706

Article linkㄩhttps://doi.org/10.1021/acs.jmedchem.5c03706

Article SourceㄩAmerican Chemical Society (ACS)


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