[Other] Synthesis of D-(R)-Tyrosine by Catalytic Asymmetric Hydrogenation and Its Practical Application

omsai Post time 1 hour(s) ago | Show all posts |Read mode

This post will be closed automatically in 2026-06-28 13:10

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Abstract
[size=0.875]Using a recently developed catalyst [Rh((R,R)-QuinoxP*)(cod)]SbF6, several derivatives of D-(R)-tyrosine were prepared with up to 99% ee via catalytic asymmetric hydrogenation. The substrates chosen for asymmetric hydrogenation were readily synthesized from the inexpensive and accessible compound 4-hydroxybenzaldehyde. The product resulting from the asymmetric hydrogenation was practically applied to the preparation of an important bioactive compound sodium (R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate through a feasible process.

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