Chengchen Duan, Yutong Xu, Shuxian Yang, Jianshu Li, Jun Luo, Shujuan Zou, Xianglong Han, Peipei Duan, Jiaojiao Yang,
Cuproptosis-like death and copper-based nanomaterials: from concept to antibacterial applications,
Progress in Materials Science,
Volume 162,
2026,
101723,
ISSN 0079-6425,
https://doi.org/10.1016/j.pmatsci.2026.101723.
(https://www.sciencedirect.com/sc ... i/S0079642526000708)
Abstract: The rise of multidrug-resistant bacterial infections presents a critical global health threat, significantly challenging clinical treatment. Copper and copper-based nanomaterials are recognized as effective antimicrobial agents. The discovery of the copper-dependent cell death pathway, known as cuproptosis, enhances our understanding of their antimicrobial effects. In bacteria without mitochondria, similar protein toxicity and tricarboxylic acid (TCA) cycle disruptions make this effect more accurately termed cuproptosis-like death. Advances in nanotechnology have improved the forms and properties of copper-based nanomaterials, offering substantial potential for antibacterial applications through this mechanism. This review begins by exploring the dual role of copper in microbiology and examining the mechanisms of cuproptosis-like death, with a focus on key detection methods. We further discuss the design strategies for developing copper-based nanomaterials, summarizing research progress and applications of representative materials such as copper sulfides, copper oxides, metal每organic frameworks, nanoclusters, metal-polyphenol networks in the antibacterial field. Additionally, we summarize representative cuproptosis-like death-inducing copper-based nanomaterial systems, including photo-responsive systems, ultrasound-activated systems, oxidative stress每amplifying systems, biofunctionalized systems, multi-metal synergistic systems, gas-releasing systems. Finally, we propose future directions for understanding the mechanisms of cuproptosis-like death and optimizing copper-based nanomaterials, aiming to contribute to the development of new methods for treating drug-resistant bacterial infections.
Keywords: Copper; Cuproptosis; Cuproptosis-like death; Nanomaterials; Synergistic therapy
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