What have we learned from 8 years of deep brain stimulation of the anterior thalamic nucleus? Experiences and insights of a single center

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J Neurosurg

. 2020 Oct 30;135(2):619-628.
doi: 10.3171/2020.6.JNS20695. Print 2021 Aug 1.
What have we learned from 8 years of deep brain stimulation of the anterior thalamic nucleus? Experiences and insights of a single centerElisabeth Kaufmann 1, Kai Bötzel 2, Christian Vollmar 1, Jan-Hinnerk Mehrkens 3, Soheyl Noachtar 1

Affiliations Expand

PMID: 33126208
DOI: 10.3171/2020.6.JNS20695

Abstract

Objective: In the absence of a standard or guideline for the treatment of epilepsy patients with deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT), systematic single-center investigations are essential to establish effective approaches. Here, the authors report on the long-term results of one of the largest single-center ANT DBS cohorts.

Methods: The outcome data of 23 consecutive patients with transventricularly implanted electrodes were retrospectively analyzed with regard to adverse events, lead placement, stimulation-related side effects, and changes in seizure frequency. Depression and quality-of-life scores were collected in a subgroup of 9 patients.

Results: All but 2 patients initially underwent bilateral implantation, and 84.4% of all DBS leads were successfully located within the ANT. The mean follow-up time was 46.57 ± 23.20 months. A seizure reduction > 50% was documented

[Other] What have we learned from 8 years of deep brain stimulation of the anterior thalamic nucleus? Experiences and insights of a single center

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