Discovery of FYJ-195 as a Highly Potent FLT3 Inhibitor against Multiple Acquired Resistance Mutations in Acute Myeloid Leukemia

Post time 2026-7-23 23:19:34

journal：Journal of Medicinal Chemistry

Authors：Jin Yang; Ling-Yu Zhang; Xing-Feng Ni; Ming-Yu Bai; Xu Wang; An-Qi Fu; Min-Hui Chen; Meng-Yuan Zhang; Nuo Qiao; Zi-Xuan Wang; Qing-Qing Li; Shu Cai; Ying Wang; Yu-Sheng Yao; Yan-Cheng Yu; Wei-Dong Chen; Shan-Liang Sun; Zhang Zhang; Nian-Guang Li; Zhi-Hao Shi

Published date：2026-6-11

DOI：10.1021/acs.jmedchem.6c00648

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6c00648

Article link：https://doi.org/10.1021/acs.jmedchem.6c00648

Article Source：American Chemical Society (ACS)。

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Post time 2026-7-23 23:19:35

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[ACS] Discovery of FYJ-195 as a Highly Potent FLT3 Inhibitor against Multiple Acquired Resistance Mutations in Acute Myeloid Leukemia

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[ACS] Discovery of FYJ-195 as a Highly Potent FLT3 Inhibitor against Multiple Acquired Resistance Mutations in Acute Myeloid Leukemia