Cagrilintide每semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 studyProf John B Buse, MD[url=]a[/url] Send email to [email protected] ∙ Harpreet S Bajaj, MD[url=]b[/url] ∙ Stine-Mathilde Dalskov, PhD[url=]c[/url] ∙ Lucienne Donaldson, MBChB[url=]c[/url] ∙ Helene H Hansen Duus, MSc[url=]c[/url] ∙ Therese Wilbek Fabricius, MD[url=]c[/url] ∙ et al. Show more
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Published June 7, 2026
DOI: 10.1016/S2213-8587(26)00125-7 External LinkAlso available on ScienceDirect External Link
Copyright: © 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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ErrataCorrection to Lancet Diabetes Endocrinol 2026; published online June 7. [url]https://doi.org/10.1016/S2213-8587(26)00125-7[/url]
June 19, 2026
SummaryBackgroundThe amylin receptor agonist cagrilintide and the GLP-1 receptor agonist semaglutide have complementary effects on glycaemic control and bodyweight. We aimed to investigate the efficacy and safety of a fixed-dose combination of cagrilintide and semaglutide (cagrilintide每semaglutide; known as CagriSema) versus semaglutide or cagrilintide for glycaemic control in people with type 2 diabetes and overweight or obesity.
MethodsREIMAGINE 2 was a randomised, double-blind, placebo-controlled and active-controlled, parallel-group study conducted in 30 countries (trial sites included university hospitals, health-care centres, research centres, and other centres). Participants aged 18 years or older with inadequately controlled type 2 diabetes (HbA1c 7﹞0每10﹞5% [53每91 mmol/mol]) receiving metformin with or without an SGLT2 inhibitor, and a BMI of 25 kg/m2 or more, were randomly assigned (8:8:2:8:8:1:1) to receive once-weekly subcutaneous cagrilintide 2﹞4 mg plus semaglutide 2﹞4 mg (hereafter cagrilintide每semaglutide [2﹞4 mg each]), semaglutide 2﹞4 mg, cagrilintide 2﹞4 mg, cagrilintide 1﹞0 mg plus semaglutide 1﹞0 mg (hereafter cagrilintide每semaglutide [1﹞0 mg each]), semaglutide 1﹞0 mg, or corresponding placebo for 68 weeks. Randomisation was done using a web-based system with blocked randomisation (block size 36) and stratification according to inclusion in the continuous glucose monitoring subgroup, HbA1c less than 8﹞5% at screening (yes or no), and country of participation (Japan; yes or no). The study participants, investigators, and study sponsor staff were masked to treatment allocation within dose level throughout the study. The primary endpoint was change in HbA1c from baseline to week 68 with cagrilintide每semaglutide (2﹞4 mg each) versus semaglutide 2﹞4 mg in the full analysis set; safety was assessed in all participants who received at least one dose of study product. This study is registered with ClinicalTrials.gov (NCT06065540) and is complete.
FindingsFrom Oct 10, 2023, to July 29, 2024, 3593 people were screened for eligibility, 2713 of whom were randomly assigned to cagrilintide每semaglutide (2﹞4 mg each; n=603), semaglutide 2﹞4 mg (n=605), cagrilintide 2﹞4 mg (n=152), cagrilintide每semaglutide (1﹞0 mg each; n=595), semaglutide 1﹞0 mg (n=609), or placebo (pooled 2﹞4 mg and 1﹞0 mg; n=149). 1164 (42﹞9%) of 2713 were female, 1549 (57﹞1%) were male, and 2207 (81﹞3%) were White. Of the randomly assigned participants, 2595 (95﹞7%) completed the study and 2376 (87﹞6%) were on treatment at week 68. Mean baseline HbA1c was 8﹞2% (SD 0﹞9). For the primary endpoint using the efficacy estimand, mean HbA1c change was significantly greater with cagrilintide每semaglutide (2﹞4 mg each) versus semaglutide 2﹞4 mg (−1﹞91 percentage points [SE 0﹞04] vs −1﹞75 percentage points [0﹞04]; estimated treatment difference −0﹞16 percentage points [95% CI −0﹞27 to −0﹞05]; p=0﹞0035). Adverse events were reported in 524 (86﹞9%) of 603 participants in the cagrilintide每semaglutide (2﹞4 mg each) group, 491 (81﹞2%) of 605 in the semaglutide 2﹞4 mg group, 125 (82﹞2%) of 152 in the cagrilintide 2﹞4 mg group, 485 (81﹞6%) of 594 in the cagrilintide每semaglutide (1﹞0 mg each) group, 477 (78﹞5%) of 608 in the semaglutide 1﹞0 mg group, and 105 (70﹞5%) of 149 in the placebo group. The most common adverse events in the active treatment groups were gastrointestinal disorders.
InterpretationCagrilintide每semaglutide (2﹞4 mg each) was superior to semaglutide 2﹞4 mg in reducing HbA1c in participants with type 2 diabetes receiving metformin with or without an SGLT2 inhibitor. The safety profile of cagrilintide每semaglutide was consistent with the GLP-1 receptor agonist class and previous safety data for cagrilintide. These findings support the added benefit of cagrilintide每semaglutide (2﹞4 mg each) versus semaglutide 2﹞4 mg for glycaemic control.
FundingNovo Nordisk.
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