Identification of pyrrolo[2,3-d]pyrimidine-based dual MERTK and FLT3 inhibitor: Hit-to-lead, machine learning, modeling, synthesis, and biological evaluation

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journal：European Journal of Pharmaceutical Sciences

Authors：Abdellah Yamani; Pawe Maliszewski; Natalia Piórkowska; Patrycja Olejkowska-Podgórska; Wojciech Pietru; Mario Luigi Naitana; Agata Mitkowska; Artur aszek; Delfina Popiel; Agata Mikoajczyk; Tomasz Kornatowski; Kinga Jastrzbska; Filip Mitua; Jakub Dominowski; Artur Janusz; Micha Górka; Joanna Hucz-Kalitowska; Magorzata Teska-Kamińska; Aleksandra Stańczak; Monika Delis; Damian Smuga; Jerzy Pieczykolan; Krzysztof Dubiel; Maciej Wieczorek

Published date：2026-4-

DOI：10.1016/j.ejps.2025.107421

PDF link：https://www.sciencedirect.com/sc ... 92809872500418X/pdf

Article link：https://doi.org/10.1016/j.ejps.2025.107421

Article Source：Elsevier BV。

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[Elsevier] Identification of pyrrolo[2,3-d]pyrimidine-based dual MERTK and FLT3 inhibitor: Hit-to-lead, machine learning, modeling, synthesis, and biological evaluation

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[Elsevier] Identification of pyrrolo[2,3-d]pyrimidine-based dual MERTK and FLT3 inhibitor: Hit-to-lead, machine learning, modeling, synthesis, and biological evaluation