Structural Elucidation and Dissolution Studies of a 1:2 Chlorthalidone–Isonicotinamide Cocrystal: A Rare Pathway to the Metastable Polymorph Chlorthalidone Form II with Enhanced Dissolution Performance

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journal：Crystal Growth & Design

Authors：Christian Rodríguez-Ruiz; Reynaldo Salas-Zúiga; Pedro Montes-Tolentino; Jorge Guillermo Domínguez-Chávez; Hugo Morales-Rojas; Herbert Hpfl; Dea Herrera-Ruiz

Published date：2026-7-1

DOI：10.1021/acs.cgd.5c01657

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.cgd.5c01657

Article link：https://doi.org/10.1021/acs.cgd.5c01657

Article Source：American Chemical Society (ACS)。

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[ACS] Structural Elucidation and Dissolution Studies of a 1:2 Chlorthalidone–Isonicotinamide Cocrystal: A Rare Pathway to the Metastable Polymorph Chlorthalidone Form II with Enhanced Dissolution Performance

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[ACS] Structural Elucidation and Dissolution Studies of a 1:2 Chlorthalidone–Isonicotinamide Cocrystal: A Rare Pathway to the Metastable Polymorph Chlorthalidone Form II with Enhanced Dissolution Performance Copy

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[ACS] Structural Elucidation and Dissolution Studies of a 1:2 Chlorthalidone–Isonicotinamide Cocrystal: A Rare Pathway to the Metastable Polymorph Chlorthalidone Form II with Enhanced Dissolution Performance