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[size=0.875]SeminarVolume 393, Issue 10182p1745-1759April 27, 2019Download Full Issue
Osteoarthritis大卫·J·亨特教授，博士[url=]a[/url] Send email to [email protected] ∙ 西塔·比尔马-泽因斯特拉教授，博士[url=]b[/url]
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Published April 27, 2019
DOI: 10.1016/S0140-6736(19)30417-9 External LinkAlso available on ScienceDirect External Link
Copyright: © 2019 Elsevier Ltd. All rights reserved.
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SummaryOsteoarthritis is a leading cause of disability and source of societal cost in older adults. With an ageing and increasingly obese population, this syndrome is becoming even more prevalent than in previous decades. In recent years, we have gained important insights into the cause and pathogenesis of pain in osteoarthritis. The diagnosis of osteoarthritis is clinically based despite the widespread overuse of imaging methods. Management should be tailored to the presenting individual and focus on core treatments, including self-management and education, exercise, and weight loss as relevant. Surgery should be reserved for those that have not responded appropriately to less invasive methods. Prevention and disease modification are areas being targeted by various research endeavours, which have indicated great potential thus far. This narrative Seminar provides an update on the pathogenesis, diagnosis, management, and future research on osteoarthritis for a clinical audience.
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