Design and synthesis of Thiazole-derived α,β-unsaturated ketones as potential antimalarial agents: integrated biophysical and computational insights into putative PfLDH targeting

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journal：Bioorganic Chemistry

Authors：Dharmanath Sutar; Abhay Bagul; Manish Kumar; Aisha Tufail; Ghazala Muteeb; Jaiprakash N. Sangshetti; Dinesh Rathod; Gajanan Mandawad; Mohammad Aatif; Amit Dubey

Published date：2026-7-

DOI：10.1016/j.bioorg.2026.109876

PDF link：https://www.sciencedirect.com/sc ... 045206826004128/pdf

Article link：https://doi.org/10.1016/j.bioorg.2026.109876

Article Source：Elsevier BV。

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[Elsevier] Design and synthesis of Thiazole-derived α,β-unsaturated ketones as potential antimalarial agents: integrated biophysical and computational insights into putative PfLDH targeting

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[Elsevier] Design and synthesis of Thiazole-derived α,β-unsaturated ketones as potential antimalarial agents: integrated biophysical and computational insights into putative PfLDH targeting Copy

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[Elsevier] Design and synthesis of Thiazole-derived α,β-unsaturated ketones as potential antimalarial agents: integrated biophysical and computational insights into putative PfLDH targeting