Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797

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journal：Bioorganic & Medicinal Chemistry

Authors：Adchata Konsue; Duangkamol Gleeson; Kiattawee Choowongkomon; Donald J.L. Jones; Pimkhuan Hannanta-anan; Robert G. Britton; M. Paul Gleeson

Published date：2026-3-

DOI：10.1016/j.bmc.2025.118544

PDF link：https://www.sciencedirect.com/sc ... 968089625004869/pdf

Article link：https://doi.org/10.1016/j.bmc.2025.118544

Article Source：Elsevier BV。

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[Elsevier] Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797

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[Elsevier] Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797