Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

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journal：Journal of Medicinal Chemistry

Authors：Florian Wittlinger; David E. Heppner; Ciric To; Marcel Günther; Bo Hee Shin; Jaimin K. Rana; Anna M. Schmoker; Tyler S. Beyett; Lena M. Berger; Benedict-Tilman Berger; Nicolas Bauer; James D. Vasta; Cesear R. Corona; Matthew B. Robers; Stefan Knapp; Pasi A. Jnne; Michael J. Eck; Stefan A. Laufer

Published date：2022-1-27

DOI：10.1021/acs.jmedchem.1c00848

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00848

Article link：https://doi.org/10.1021/acs.jmedchem.1c00848

Article Source：American Chemical Society (ACS)。

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[ACS] Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

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[ACS] Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites