Discovery ofLAS194046: A Potent and Selective pan-JanusKinase (JAK) Inhibitor with a Suitable Profile for Inhaled Administration

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journal：Journal of Medicinal Chemistry

Authors：Jordi Bach; Daniel Perez; Cristina Esteve; Oriol Llera; Lorena Taboada; Paul R. Eastwood; Jacob Gonzalez; Lluis Pages; Blanca Lopez; Rosario Ramon; Laura Grau; Alberto Ortega; Alfredo Gonzalez; Francesc Biosca; Jordi Serrat; Stephen Connolly; Silvia Fonquerna; Paul Beswick; Jordi Gracia; Estrella Lozoya; Josep M. Huerta; Sonia Espinosa; Adelina Orellana; Monica Maldonado; Juan Perez-Andres; Carlos Rodergas Mir; Elena Calaf; Joan Alberti; Mariona Auli; Cristina Carreno; Elena Calama; Jorge De Alba; Montserrat Miralpeix; Marta Calbet; Isabel Ramis

Published date：2026-8-27

DOI：10.1021/acs.jmedchem.6c00169

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6c00169

Article link：https://doi.org/10.1021/acs.jmedchem.6c00169

Article Source：American Chemical Society (ACS)。

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[ACS] Discovery ofLAS194046: A Potent and Selective pan-JanusKinase (JAK) Inhibitor with a Suitable Profile for Inhaled Administration

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[ACS] Discovery ofLAS194046: A Potent and Selective pan-JanusKinase (JAK) Inhibitor with a Suitable Profile for Inhaled Administration