QT Prolongation, Ventricular Arrhythmia, and Cardiac Arrest Signals During Ceftriaxone Co-therapy with Individual Proton Pump Inhibitors: A Multidatabase Study

Post time 29 min. ago

Journal: Cardiovascular Toxicology

Authors: Yechao Chen; Qiaoling Gu; Mingnuo Zhao; Ajin Zhao; Zirui Kong; Haobin Shen; Yanan Zhang; Shuang Wang; Li Li; Han Xie; Peipei Liu; Haixia Zhang; Dayu Chen

Published date: 6 September 2026

DOI: 10.1007/s12012-026-10174-z

Article link: [url=]https://doi.org/10.1007/s12012-026-10174-z[/url]

Article Source: Springer / Cardiovascular Toxicology

Remark: Multidatabase study investigating QT prolongation, ventricular arrhythmia, and cardiac arrest signals associated with ceftriaxone combined with individual proton pump inhibitors (PPIs). The ceftriaxone + lansoprazole combination showed a significant association with QT/QTc prolongation signals. Rabeprazole appeared relatively safer among the PPIs studied. The authors recommend prospective confirmation.

[Other] QT Prolongation, Ventricular Arrhythmia, and Cardiac Arrest Signals During Ceftriaxone Co-therapy with Individual Proton Pump Inhibitors: A Multidatabase Study

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