De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells

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journal：Science

Authors：Kristoffer Haurum Johansen; Darian Stephan Wolff; Beatrice Scapolo; Monica L. Fernández-Quintero; Charlotte Risager Christensen; Johannes R. Loeffler; Esperanza Rivera-de-Torre; Max D. Overath; Kamilla Kjrgaard Munk; Oliver Morell; Marie Christine Viuff; Iigo Lacunza; Alberte T. Damm Englund; Mathilde Due; Anant Gharpure; Stefano Forli; Carlos Rodriguez Pardo; Tripti Tamhane; Emma Qingjie Andersen; Kasper Haldrup Bjrnsson; Jordan Sylvester Fernandes; Lasse Frank Voss; Suthimon Thumtecho; Andrew B. Ward; Maria Ormhj; Sine Reker Hadrup; Timothy P. Jenkins

Published date：2025-7-24

DOI：10.1126/science.adv0422

PDF link：https://www.science.org/doi/pdf/10.1126/science.adv0422

Article link：https://doi.org/10.1126/science.adv0422

Article Source：American Association for the Advancement of Science (AAAS)。

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[AAAS] De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells

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