Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models

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journal：Science Translational Medicine

Authors：Xin Du; Pei K. Goh; Chenkai Ma; Eamon Coughlan; Spencer Greatorex; Laura H. Porter; Brendan Russ; Katherine D. Cummins; Kevin Sek; Clare Y. Slaney; Andrew M. Scott; Jane Oliaro; Paul J. Neeson; Gail P. Risbridger; Renea A. Taylor; Joseph A. Trapani; Stephen J. Turner; Phillip K. Darcy; Florian Wiede; Tony Tiganis

Published date：2025-10-29

DOI：10.1126/scitranslmed.adk0627

PDF link：https://www.science.org/doi/pdf/10.1126/scitranslmed.adk0627

Article link：https://doi.org/10.1126/scitranslmed.adk0627

Article Source：American Association for the Advancement of Science (AAAS)。

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[AAAS] Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models

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[AAAS] Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models