The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2

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journal：Journal of Medicinal Chemistry

Authors：Christopher M. Adams; Karen Anderson; Gerald Artman; Jean-Claude Bizec; Rosemarie Cepeda; Jason Elliott; Elizabeth Fassbender; Malay Ghosh; Shawn Hanks; Leo A. Hardegger; Vinayak P. Hosagrahara; Bruce Jaffee; Keith Jendza; Nan Ji; Leland Johnson; Wendy Lee; Donglei Liu; Fang Liu; Debby Long; Fupeng Ma; Nello Mainolfi; Erik L. Meredith; Karl Miranda; Yao Peng; Stephen Poor; James Powers; Yubin Qiu; Chang Rao; Siyuan Shen; Jeremy M. Sivak; Catherine Solovay; Peter Tarsa; Amber Woolfenden; Chun Zhang; Yiqin Zhang

Published date：2018-2-22

DOI：10.1021/acs.jmedchem.7b01731

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01731

Article link：https://doi.org/10.1021/acs.jmedchem.7b01731

Article Source：American Chemical Society (ACS)。

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[ACS] The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2

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[ACS] The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Copy

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[ACS] The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2