[ACS] Discovery andOptimization of a WRN Helicase InhibitorSeries through Structure-Guided Drug Design from a Covalent FragmentBinding Insight

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journal:Journal of Medicinal Chemistry

Authors:Momar Toure; Xin Cindy Yan; Yonghong Bai; Brian A. Sosa-Alvarado; Cen Gao; Theresa Baker; Erin Brophy; John R. Butler; Yuchen Yuan; Michael H. Reutershan; Anthony Tubbs; Laurie Schenkel; Giulia Bottoni; Erica Evans; Peter Hammerman; Allison Drew; Timothy Guzi; Meredeth A. McGowan

Published date:2026-8-13

DOI:10.1021/acs.jmedchem.6c00443

PDF link:https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6c00443

Article link:https://doi.org/10.1021/acs.jmedchem.6c00443

Article Source:American Chemical Society (ACS)


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