Prospective dermatologically controlled efficacy study of a hydrating spray emulsion with 0.2% elemental silver in atopic dermatitis

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Objective of the study: Investigation of the efficacy of a silver containing nurturing cream (MicroSilver BG™ 0.1%) in patients with mild to moderate atopic dermatitis. Methods: The primary endpoint was the change in the local SCORAD on the arms after four weeks of treatment. The local SCORAD includes five symptoms - erythema, edema and papules, oozing and crusting, excoriation, and lichenification - in the evaluation. The intensity of the individual symptoms is evaluated on a scale from 0 to 3. Secondary endpoints were the change in the SCORAD index after four weeks of treatment, qualitative detection of staphylococcus aureus colonisation on the arms as well as an evoluation of the product and its use from the patient perspective. The patients applied the silver containing cream (MicroSilver BG™ 0.1%) themselves twice daily in the morning and evening for four weeks. The first follow-up examination took place after two weeks of treatment and the second and last follow-up examination after four weeks of treatment. Results: The mean local SCORAD index was 8.65 at the start of the study. After two weeks of treatment, it had fallen to 6.05 and after four weeks of treatment it had fallen statistically significantly to 4.08 (reduction: 57.5%). The mean SCORAD index was 50.80 at the start of the study. After only two weeks of treatment, it had fallen statistically significantly to 36.32 and after four weeks of treatment to 24.85 (reduction: 53.45%). The silver containing cream (MicroSilver BG™ 0.1%) was evaluated as "Very good" or "Good" by 68.8% of patients. The mean score for the individual product properties was between 1.7 and 2.9 and the mean total score for the cream was 2.5. 75.0% of patients stated that they would like to continue to use the silver containing cream (MicroSilver BG™ 0.1%). No patients experienced staphylococcus aureus colonisation during the four weeks of treatment. Atopic dermatitis severity and staphylococcus aureus colonisation are closely correlated. Products with an antimicrobial principle of action - like the silver containing cream (MicroSilver BG™ 0.1%) - are therefore a useful approach to the nurturing treatment of atopic skin conditions.

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[Other] Prospective dermatologically controlled efficacy study of a hydrating spray emulsion with 0.2% elemental silver in atopic dermatitis