The Discoveryof RP-2119: A Potent, Selective, andOrally Bioavailable Polθ ATPase Inhibitor

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journal：Journal of Medicinal Chemistry

Authors：Philippe Mochirian; Robert Papp; Marie-Claude Mathieu; Gino B. Ferraro; Evelyne Dietrich; Bingcan Liu; David Bendahan; Alexander L. Perryman; Simon Surprenant; Sara Fournier; Bita Lotfollahzadeh Barzili; Alexanne Bonneau-Fortin; Shou Yun Yin; Marie-Eve Leclaire; Charmi Patel; Hugo Poirier; Sai Save; Yann Mathieu; Nicolas Morin; Claude Godbout; Helen E. Burston; Karl E. Zahn; Mohamed A. Attia; Thomas Pinter; Francis Barabe; Paranjay Parikh; Chandresh Jagani; Gyunghoon Kang; Giovanna Scapin; Yael Mamane; Agnel Sfeir; Pavel Mader; Frank Sicheri; Michal Zimmermann; Anne Roulston; Stephen J. Morris; W. Cameron Black; Michel Gallant

Published date：2025-9-25

DOI：10.1021/acs.jmedchem.5c02103

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c02103

Article link：https://doi.org/10.1021/acs.jmedchem.5c02103

Article Source：American Chemical Society (ACS)。

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[ACS] The Discoveryof RP-2119: A Potent, Selective, andOrally Bioavailable Polθ ATPase Inhibitor