[Elsevier] Discovery of 1,4-diaryl-1,3-dihydro-2H-imidazole-2-thione anticonvulsants integrating AMPA receptor antagonism, Nav1.2 channel blockade, redox modulation, and favorable pharmacokinetic properties

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journal:European Journal of Medicinal Chemistry

Authors:Shahenda Mahmoud; Tarek F. El-Moselhy; Eman A. El-Bastawissy; Nesma M.E. Abo El Nasr; Marawan A. Elbaset; Mahmoud A.A. Ibrahim; Shahzeb Khan; Tarad Abalkhail; Oleg I. Barygin; Arseniy S. Zhigulin; Vitalina V. Furman; Tatiana V. Karelina; Sun Huang; Gerald W. Zamponi; Peter A. Sidhom

Published date:2026-12-

DOI:10.1016/j.ejmech.2026.119324

PDF link:https://www.sciencedirect.com/sc ... 223523426007695/pdf

Article link:https://doi.org/10.1016/j.ejmech.2026.119324

Article Source:Elsevier BV


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