Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors

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Edited by Sweetums33 at 2026-10-20 17:50

journal：Immunity

Authors：Leon Tejwani; Catherine M. Heffner; Christopher Balak; Lukas L. Skuja; David Tatarakis; Anil Rana; Seungyoon B. Yu; Gabriel A. Fitzgerald; Connie Ha; Gabrielly Lunkes de Melo; Elizabeth W. Sun; Matthew J. Simon; Jason C. Dugas; Johann Chow; Elliot Thomsen; Lily Sarrafha; Eric Liang; Neal Gould; Jung Suh; Thomas Sandmann; Christopher K. Glass; Gilbert Di Paolo

Published date：2026-8-

DOI：10.1016/j.immuni.2026.07.009

PDF link：https://www.sciencedirect.com/sc ... 074761326003080/pdf

Article link：https://doi.org/10.1016/j.immuni.2026.07.009

Article Source：Elsevier BV。

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[Elsevier] Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors

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