[ACS] Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson*s Disease

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journalㄩJournal of Medicinal Chemistry

AuthorsㄩSolomon D. Kattar; Anmol Gulati; Kaila A. Margrey; Mitchell H. Keylor; Michael Ardolino; Xin Yan; Rebecca Johnson; Rachel L. Palte; Spencer E. McMinn; Lisa Nogle; Jing Su; Dong Xiao; Jennifer Piesvaux; Susi Lee; Laxminarayan G. Hegde; Janice D. Woodhouse; Robert Faltus; Lily Y. Moy; Tina Xiong; Paul J. Ciaccio; Kara Pearson; Mayankbhai Patel; Karin M. Otte; Cheryl E.G. Leyns; Matthew E. Kennedy; David Jonathan Bennett; Erin F. DiMauro; Matthew J. Fell; Peter H. Fuller

Published dateㄩ2023-11-9

DOIㄩ10.1021/acs.jmedchem.3c01486

PDF linkㄩhttps://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01486

Article linkㄩhttps://doi.org/10.1021/acs.jmedchem.3c01486

Article SourceㄩAmerican Chemical Society (ACS)﹝


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