Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab

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journal：Cancer Cell

Authors：Kotaro Nomura; Tomoyo Fukami; Shinichiro Kato; Shunya Tanaka; Akito Fukuda; Yuki Koike; Masaki Kondo; Kazuhiro Kumagai; Takuma Irie; Genki Okumura; Tetsuro Taki; Shingo Sakashita; Masayuki Shirasawa; Tatsuya Yoshida; Kouya Shiraishi; Ryo Ariyasu; Yuki Takeyasu; Takahiro Niimi; Tetsuya Sakai; Masahiro Torasawa; Hiroaki Kanemura; Shin Saito; Takuo Hayashi; Akinori Kanai; Kazuya Takamochi; Tomohiro Haruki; Keiju Aokage; Hitomi Nishinakamura; Shohei Koyama; Genichiro Ishii; Yutaka Suzuki; Yasushi Goto; Makoto Nishio; Kenji Suzuki; Yasuhiro Tsutani; Yasushi Yatabe; Hiroyuki Mano; Masahiro Tsuboi; Shogo Kumagai; Hiroyoshi Nishikawa

Published date：2026-10-

DOI：10.1016/j.ccell.2026.09.016

PDF link：https://www.sciencedirect.com/sc ... 535610826004356/pdf

Article link：https://doi.org/10.1016/j.ccell.2026.09.016

Article Source：Elsevier BV。

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[Elsevier] Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab

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[Elsevier] Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab