Fragment-BasedDiscovery and Structure-Led Optimizationof MSC778, the First Potent, Selective, and Orally Bioavailable FEN1Inhibitor

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journal：Journal of Medicinal Chemistry

Authors：Sam E. Mann; Julien Lefranc; Omar Alkhatib; Roch Boivin; Jorg Bomke; Robert T. Byrne; Carolina P. Cassona; Xiaoling Chen; Irina Cornaciu; Paula Costales; Owen A. Davis; Lizbeth DeSelm; Elias Elinati; Bruce Follows; Alessandro Galbiati; Christoph Goldner; Jasvinder K. Hayre; Catherine Jorand-Lebrun; Claudio A. Lademann; Birgitta Leuthner; Jayesh B. Majithiya; Catarina F. Malta; Bethany Mason; Claire L. McWhirter; Bernd Neff; J. Willem M. Nissink; Ulrich Pehl; Carl Petersson; Andrea Pica; Maria Filipa Pinto; Eeson Rajendra; Christin Rakers; Ana Toste Rego; Helen M. R. Robinson; Ada Sala-Hojman; Theresia A. Schaedler; Paul J. L. Schurmann; Diana O. Silva; Graeme C. M. Smith; Fiona Sorrell; Gina R. Webster; Frank T. Zenke; Robert A. Heald; Lars T. Burgdorf

Published date：2025-10-9

DOI：10.1021/acs.jmedchem.5c01526

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c01526

Article link：https://doi.org/10.1021/acs.jmedchem.5c01526

Article Source：American Chemical Society (ACS)。

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[ACS] Fragment-BasedDiscovery and Structure-Led Optimizationof MSC778, the First Potent, Selective, and Orally Bioavailable FEN1Inhibitor