[AAAS] T cell–mediated depletion of intratumoral regulatory T cells using a CCR8xCD3 T cell–engaging bispecific antibody (TCB) promotes antitumor immunity in preclinical mouse models

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journal：Science Translational Medicine

Authors：Baomei Wang; Isabel Ishizuka; Emel Esen; Ji Li; Cecilia Chiu; Yonglian Sun; Zhonghua Lin; Dhaya Seshasayee; Aija Kusi; Yu Zhong; Wendy Halpern; Adeyemi O. Adedeji; Lanlan Yu; Peter Tran; Zhaojun Yin; Shang-Fan Yu; Geoff Del Rosario; Yoko Oei; Yagai Yang; Jill Schartner; Mary Ann Go; Giulia Protti; Soren Muller; Cong Wu; Ran Li; Genee Lee; James T. Koerber; Sascha Rutz; Teemu T. Junttila

Published date：2026-10-28

DOI：10.1126/scitranslmed.aea7127

PDF link：https://www.science.org/doi/pdf/10.1126/scitranslmed.aea7127

Article link：https://doi.org/10.1126/scitranslmed.aea7127

Article Source：American Association for the Advancement of Science (AAAS)。

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[AAAS] T cell–mediated depletion of intratumoral regulatory T cells using a CCR8xCD3 T cell–engaging bispecific antibody (TCB) promotes antitumor immunity in preclinical mouse models