[ACS] Expanding Addressable KRAS Mutations through the Structure- and Property-Based Design of Dual-State (GDP/GTP), Reversible Pan-KRAS Inhibitors

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journal:Journal of Medicinal Chemistry

Authors:Ryan P. Wurz; Jennifer R. Allen; John G. Allen; Albert Amegadzie; Ning Chen; Josephine Eshon; Kexue Li; Xiaofen Li; Yunxiao Li; Francesco Manoni; Jose M. Medina; Primali Navaratne; Liping H. Pettus; René Rahimoff; John Stellwagen; Quentin Tercenio; Nicholas Weires; Benjamin Wigman; Michael Yamano; Wei Zhao; Gitte Husemoen; Sebastian Leth-Petersen; David Bauer; Mike J. Frohn; Olga A. Mukhina; Michelle Boursier; Amit Vaish; Leszek Poppe; Christopher Mohr; Ying-Chu Chen; Gilbert Joseph Diaz; Kevin Gaida; Paul E. Hughes; Jawahar Khetan; Deanna Mohn; Tao Osgood; Anne Y. Saiki; Karen Rex; Rati Verma; Paul Wang; Huan Rui; Jason Yu; Upendra P. Dahal; Yanfei Li; Prashant Agarwal; Teresa Wegesser; Brian A. Lanman

Published date:2026-7-23

DOI:10.1021/acs.jmedchem.6c01325

PDF link:https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6c01325

Article link:https://doi.org/10.1021/acs.jmedchem.6c01325

Article Source:American Chemical Society (ACS)


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